| However, there is insufficient information to determine the effects of metformin on the breastfed infant and no available information on the effects of metformin on milk production | Journal of the Philippine Medical Association |
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| Increase dosage in increments of 500 mg weekly on the basis of glycemic control and tolerability, up to a maximum of 2000 mg per day, given in divided doses twice daily | "Sulfonylurea versus metformin monotherapy in patients with type 2 diabetes: a Cochrane systematic review and meta-analysis of randomized clinical trials and trial sequential analysis" |
have a history or risk for diabetic ketoacidosis high levels of certain acids, known as ketones, in the blood or urine.
| "Determination of polar organic micropollutants in surface and pore water by high-resolution sampling-direct injection-ultra high performance liquid chromatography-tandem mass spectrometry" | Br J Clin Pharmacol 1987; 23 5 : 545-551 DOC ID 090006d180b7ff26 |
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| "Short- and long-term outcomes of metformin compared with insulin alone in pregnancy: a systematic review and meta-analysis" | ; Mohammadi-Shemirani, Pedrum; Morrow, Marisa R |
Drugs Affecting Glycemic Control Clinical Impact: Certain drugs tend to produce hyperglycemia and may lead to loss of glycemic control.
3| Acta Obstetricia et Gynecologica Scandinavica | Eldorado Doc ID 0900babe8046cf7b 10 |
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| : Die blutzucker-senkende Wirkung der Biguanide" | Published studies with metformin use during pregnancy have not reported a clear association with metformin and major birth defect or miscarriage risk [see Data] |