A withdrawal syndrome characterized by drowsiness, irritability, and headache typically lasts no longer than a day | Food and Chemical Toxicology: An International Journal Published for the British Industrial Biological Research Association |
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Long-term caffeine use can lead to mild physical dependence | Substance use disorder in DSM-5 combines the DSM-IV categories of substance abuse and substance dependence into a single disorder measured on a continuum from mild to severe |
Additionally, the diagnosis of dependence caused much confusion | There is sufficient evidence to support this as a condition, however it is not yet clear to what extent it is a clinically significant disorder |
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